Microglia expresses some pattern recognition receptors that are engaged by pathogen-associated molecular patterns, triggering microglia activation
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Critically, the study documented no significant changes in oral glucose tolerance tests, no alterations in fasting insulin levels, and no changes in serum IGF-1 concentrations across all treatment groups
Interestingly, although KDS2010 did not reduce elevated astrocytic putrescine levels in PTSD-like mice, suggesting that it does not suppress upstream sources of putrescine synthesis, the restoration of MAOB-dependent GABA homeostasis by KDS2010 may still be sufficient to achieve behavioral recovery (Supplementary Fig
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