It is primarily cleared through receptor-mediated endocytosis and proteolytic degradation, not through hepatic CYP450 metabolism
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The panel further stated that these ULs dont apply to people taking anticoagulant or antiplatelet medications (e.g., aspirin), to individuals with vitamin K malabsorption syndromes, or to patients with cardiovascular disease (121)
Equally unresolved is how redox thresholds are established namely, when GSH-mediated buffering shifts from protective to permissive for cell death, and how changes in NADPH availability, metal speciation, or mitochondrial dependence reprogram this balance