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Moreover, it has been suggested that starvation reduces liver glycogen storage and hence reduces UGT conjugative ability leading to a greater fraction of the dose being oxidised to NAPQI [77]

Individuals over the age of 50 years should augment their dietary intake with vitamin B 12 from supplements or fortified foods because of the increased likelihood of food-bound vitamin B 12 malabsorption with advanced age

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These patients reduced their initial weight by 5% through a low-calorie diet during the 4-12 weeks pre-trial induction period

Patients who should not receive BPC-157 include: those with active or recent malignancies (due to angiogenic concerns), pregnant or breastfeeding women (no reproductive toxicology data in humans), patients on anticoagulation therapy (theoretical bleeding risk from angiogenesis at ulcer sites), and minors (no pediatric data of any kind)