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Fujii, U

Safety data for GLP-1 receptor agonists now spans nearly two decades of clinical use, beginning with exenatide in 2005 and expanding through semaglutide trials that enrolled tens of thousands of participants

Discontinuation typically results in weight regain, with patients recovering approximately two-thirds of lost weight within 12 months after stopping treatment

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A mixture of N , N , N , N -tetramethyl- p -phenylenediamine (TMPD, 0.5 mM) along with ascorbic acid (ASC, 2 mM) was used to measure complex IV respiration, followed by inhibition with sodium azide (5 mM)