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Comparative Mechanisms with Other Agents Compared with metformin, which improves insulin sensitivity primarily through hepatic and muscular pathways, GLP-1 RAs act centrally and peripherally to influence appetite, glucose metabolism, and systemic inflammation

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It occurs naturally in human plasma, with levels that decline with age

- intrinsic factor deficiency - D51.0 - factor (congenital) - D51.0 - combined (spinal cord) (subacute) - E53.8 - with anemia (pernicious) - D51.0 - Disease, diseased - See Also: Syndrome

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