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According to The BMJ, doctors in India have reported a sharp rise in off-label use of GLP-1 medicines for weight loss among people without diabetes, with demand increasing despite high costs and limited medical supervision

As the off-label use of these agents continues to grow in type 1 diabetes, particularly in patients with obesity or insulin resistance, our results support the need for continued investigation and consideration of their role as adjunctive therapies, Garg said

11(12):2870 Nauck MA, Meier JJ (2018) Incretin hormones: their role in health and disease

The peptides themselves need to be sourced properly and undergo vigorous testing for purity both in synthesis and in final preparation

Research into these medications suggests several potential pathways for sleep disruption