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Betaine is a modified nonessential amino acid obtained from dietary sources (eg, beets, spinach, wheat germ, whole grains) and is also formed endogenously in the liver and kidneys from dietary choline, which is found in meat, poultry, eggs, fish, and dairy foods.10 The processes of transsulfuration and remethylation are synchronized to tightly regulate homocysteine levels

It has been well demonstrated that MONs can specifically respond to the reducing microenvironment intracellularly or within the tumor tissue due to the redox-responsive reaction caused by disulfide bonds ( SS) within these biological niches (Huang et al