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Hanai T, Nishimura K, Miwa T, et al

Interestingly, GFR remained increased even 14 days after cessation of rhIGF-1 therapy compared to placebo-treated controls, suggesting that rhIGF-1 resulted in renal hypertrophy, since the hemodynamic effects should have worn off within 14 days of cessation

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Elevated levels of both enzymes point to a liver or biliary tract disease