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At maintenance doses of 2.0mg or 2.4mg, the volume increases significantly

The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For

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Unlike oral supplements, B12 injections deliver the vitamin directly into the bloodstream , bypassing digestive absorption issues that can limit effectiveness