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Schwartz MW, Woods SC, Porte D Jr., Seeley RJ, Baskin DG

To investigate the importance of direct cholesterol interactions in modulating beta cell GLP-1R function, we have screened 12 residues selected from the cholesterol binding sites identified in our cgMD simulations, covering a wide range of occupancy, residence time, ability to tolerate the planned mutation, and varied locations within binding sites in active versus inactive states

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Tack J, Verbeure W, Mori H, Schol J, Van den Houte K, Huang IH, et al

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Developing strategies to enhance secretion from intestinal L cells could therefore provide alternative therapies for a range of conditions, including Type 2 diabetes and obesity