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For molecules excluded from oral development, this review has surveyed realistic alternatives that deserve systematic consideration: pulmonary delivery for rapid-onset needs, nasal delivery for rescue applications, buccal/sublingual delivery for potent peptides accommodating variability, and most importantly, long-acting injectables, depots, implants, and pumps that often outperform oral approaches on pharmacokinetic predictability and total cost

H2 blockers such as cimetidine (Tagamet HB), nizatidine (Axid AR), and famotidine (Pepcid AC) take 1-2 hours to start working, but provide relief for up to 24 hours

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