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This potentially reduces medication side effects, making the therapy more comfortable and sustainable for your patients

Mechanism of action: Activates both GLP-1 receptors AND GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously GIP receptors in fat tissue directly regulate lipid metabolism and fat cell energy storage Dual activation creates a synergistic effect on appetite suppression and energy expenditure Produces stronger improvement in insulin sensitivity compared to GLP-1-only medications FDA-approved brand names: Zepbound approved for chronic weight management Mounjaro approved for type 2 diabetes Why does the dual mechanism matter

However, every patient is different and may experience different levels of weight loss with each medication

Koren H, Alth G, Schenk GM, Jindra RH

In the United States, clinical guidelines (such as those from the ASMBS and IFSO) generally suggest you may be a candidate for gastric sleeve if you meet the following criteria: Have a BMI of 35 or more (regardless of other conditions)