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Many scholars asserted that immune activation is the potential mechanism for urate-induced neuroprotection rather than its antioxidation property

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A registry-based review identified 224 eligible clinical trials worldwide, with a steady increase in research focused primarily on knee osteoarthritis

Conversely, TAK1 deficiency or dysregulation leads to SREBP hyperactivation, resulting in increased TG and cholesterol accumulation, excessive lipid synthesis, and heightened susceptibility to hepatic disorders such as fatty liver degeneration and liver fibrosis [199]

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