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The label starts at 2.5 mg weekly, long-duration obesity evidence starts at 5 mg, and registered human activity has been measured as low as 1 mg in an early diabetes study. Each number answers a different question

This guide exists because that moment of uncertainty should never happen again

If overdose is suspected or if neurologic symptoms emerge, stop further dosing and seek medical evaluation

If normal, start 1000 mcg oral b12 daily as prevention given multiple risk factors (age, metformin, PPI, now semaglutide)

3: Matek D, Matek I, Japjec M, Matek M, Prenc J, Staresinic B, Staresinic E, Prtoric A, Sikiric S, Beketic Oreskovic L, Oreskovic I, Strbe S, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A, Bojanic I, Dobric I, Staresinic M