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International Journal of Women's Dermatology (2024)

Its bioavailability is very less, and it takes a relatively long time for significant concentrations of vitamin E to accumulate in the target tissues ( Various structurally related derivatives of vitamin E have been developed, some of which have improved antioxidant effects with in vitro AT assays or animal models

The evidence indicates that within the iron-rich, ROS-prone microenvironment of EMS, Erastin inhibits the system Xc transporter, depletes intracellular glutathione (GSH), and inactivates GPX4, thereby driving ferroptosis in ectopic endometrial stromal cells