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[149] showed that 2-acrylamido-2-methylpropanesulfonic-acid-derived CDs, effectively delivered riluzole to GBM cells, significantly reducing cell viability while exhibiting negligible intrinsic toxicity, thereby highlighting their biocompatibility and therapeutic stability as nanocarriers [149]

Therefore, the addition of DMSO to the serum-containing medium may lead to the erroneous attribution of a positive effect to the compound of interest, rather than complex changes in cellular sulfur metabolism caused by the unintentional omission of additional sulfur-containing compound supplied with the solvent

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In addition, berberine can aggravate the cytotoxicity induced by 6-OHDA in PC12 cells and aggravate of dopaminergic neuron death (Kwon et al., 2010)