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In the OaGST structure, the bound GSH molecule forms hydrophobic interactions with Phe112 and Trp164 and two hydrogen bonds between His105 and Ser109 21

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Neurochem Int 48:604610 Olney JW (1969) Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate

This process, often referred to as target validation , is a foundational step in early drug development