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We know that these drugs are affecting insulin in the periphery in good ways, and we know that insulin goes into the brain, Bocarsly says

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The rationale is that two smaller doses produce a more even medication level throughout the week, avoiding the peak-and-trough pattern that creates intense digestive effects early in the week and diminishing effects late in the week

Chronic underfuelling can also lead to Relative Energy Deficiency in Sport (REDs), a syndrome that occurs when athletes dont eat enough to keep up with their training and daily energy needs

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