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Finally, poor oral bioavailability, incomplete toxicology, uncertain long-term effects, and the absence of controlled human trials remain major limitations

High-dose therapy may also cause a brief increase in blood pressure, though this usually returns to baseline within a few hours

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Shelf life up to 24 months when stored lyophilized

There is no direct, targeted mechanism hitting the fat cells themselves the way AOD 9604 dosing protocols achieve through beta-3 receptor activation