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While BPA binding to extranuclear ER can trigger MAPK pathway activation 78 , the observed activation of the intracellular kinase pathways observed here more probably occurred via BPA binding to GPER, the G-protein coupled ER, as membrane bound ERs have not been identified in zebrafish 74

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Signs include: Hives or widespread rash beyond the injection site Swelling of face, lips, tongue, or throat Difficulty breathing or wheezing Rapid heartbeat Feeling faint or losing consciousness These symptoms require immediate medical attention

Early data from Alzheimer's trials has generated genuine excitement, proposing that GLP-1 signaling may modulate the neuroinflammation that drives cognitive decline