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doi:10.1161/CIRCULATIONAHA.118.036859

Defense and protection function The "first line of defense" intestinal epithelial physical barrier against external invasion resists external invasion through multiple mechanisms: first, the "physical barrier" of the mucus layer

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Rhythm Pharmaceuticals Setmelanotide Setmelanotide, an Melanocortin-4 Receptor (MC4R) agonists designed to treat hyperphagia and severe obesity , is approved by the US FDA to reduce excess body weight and maintain weight reduction long term in adult and pediatric patients 2 years of age and older with syndromic or monogenic obesity due to Bardet-Biedl syndrome (BBS) or genetically confirmed pro-opiomelanocortin (POMC), including proprotein convertase subtilisin/kexin type 1 (PCSK1), deficiency or leptin receptor (LEPR) deficiency