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Ethics statement The studies involving humans were approved by Ethical Committees of the Instituto de Biologa y Medicina Experimental, Buenos Aires (Ref: CE 001/April 2019)

Irregularity in menstrual cycle Vitamin B12 deficiency can contribute to hormonal imbalances in women, affecting the production of estrogen, progesterone, and even testosterone

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Vascular calcification Vascular calcification is commonly observed in patients with chronic kidney disease (CKD), diabetes, and atherosclerosis [99,100,101]

This observation led the team to hypothesize that Ipamorelin might be able to increase the velocity of gastric emptying