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Each medication has its recommended starting dose, which is usually adjusted gradually

However, caution is advised, as both may affect the digestive system and increase the likelihood of gastrointestinal side effects

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A post hoc analysis suggested that the improvement in cognition caused by 23 mg/d donepezil over 10 mg/d donepezil was not correlated with the age, weight, or sex of AD patients or the duration of treatment with previous low doses of donepezil

However, you should always design your protocol under direct clinical guidance to avoid unwanted interactions