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Familial intrahepatic cholestatic diseases could, therefore, be considered as a spectrum in which the paediatric PFIC is the extreme characterized by the most severe manifestations

They acknowledged limitations including the use of age-based menopausal proxies and the 36-month follow-up window, and called for prospective studies with standardized GLP-1 RA exposure definitions and longer observation periods to validate these findings

The detailed mechanism underlying the HMP-2-mediated regulation on the two GATA TFs upon germline removal will be an interesting issue in future studies

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