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IOC is a leading cause of mortality in individuals with chronic anemia-related disorders, such as -thalassemia and SCD, who undergo long-term transfusions, affecting approximately 2.5% of chronically transfusion-dependent SCD patients [19, 36, 41]

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doi: 10.1080/10641963.2018.1481420 122 IshikawaSE

Nutrients, 2023