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CagriSema 2.4/2.4mg produced a mean body weight reduction of approximately 22.7% from baseline at 68 weeks, compared to around 23% with placebo

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Surprisingly, mice with specific genetic deletion of Gpx1 appear phenotypically normal and with normal life span (Ho et al., 1997), suggesting that there are alternative compensatory mechanisms for H 2 O 2 scavenging in Gpx1 deficiency