Lifestyle Sedentary behavior such as sitting or staying in one position for extended periods can lead to fluid buildup, particularly in the lower extremities (hip, thigh, knee, leg, ankle, and foot)
Another most anticipated candidate in Novo Nordisk obesity pipeline is CagriSema , a powerful combination of semaglutide and cagrilintide, designed to enhance appetite suppression and improve metabolic control
Individual responses may vary in terms of how much weight is lost, with people on tirzepatide tending to lose larger amounts
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But studies in mice and rabbits suggest that the drugs may raise the risk of birth defects and pregnancy loss and restrict fetal growth