The local population of these isolated islands is of northern European ancestry and therefore expected to have a relatively high prevalence of MS if genetics played a dominant role
This 25 % body weight reduction resulting from a staged approach with 12-week intensive lifestyle intervention followed by tirzepatide is the largest reduction seen in GLP-1 trials to-date
The first conditional recommendation advises the use of GLP-1 drugs by adults, except pregnant women, for long-term obesity treatment, while the second suggests interventions like a healthy diet and physical activity to be offered alongside the medicines
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