Gentile M, Offidani M, Vigna E, Corvatta L, Recchia AG, Morabito L, Morabito F, Gentili S (2015) Ixazomib for the treatment of multiple myeloma
Next, to analyse the functional impact of SPHKAP downregulation on islet function, we employed a lentiviral shRNA approach to knock down SPHKAP on intact islets, as most functional outputs from primary islets cannot be optimally recapitulated with dispersed islet cells due to the loss of important intra-islet cell-cell interactions
Treatment response and tolerability are key considerations
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Roybon L, Mastracci TL, Ribeiro D, Sussel L, Brundin P, Li JY (2009)