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Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates

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Most of the loss is fat (good)

For the four samples, the severity of the subcutaneous tissue necrosis and inflammatory cell infiltration was assessed by a trained toxicopathologist using a light microscope and scored on a numerical scale, where code 1 reflects no abnormality detected and code 5 reflects marked severity: 1 , no abnormality detected 2, minimal severity 3, mild severity 4, moderate severity 5, marked severity The co-formulation vehicles were evaluated for the level of subcutaneous tissue necrosis and inflammatory cell infiltration that they elicited upon subcutaneous injection