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J Exp Med 1955;102:595-600

Among the most promising non-incretin receptor targets are amylin (Amy) receptors (AMYRs), supported by data from phase I and phase II clinical trials showing efficacy of the long-acting amylin and calcitonin receptor agonist, cagrilinitide (Cagri), both as monotherapy 2,3 and in combination with the selective GLP-1R agonist, semaglutide 4,5

Researchers hope to determine whether the benefits observed in preclinical studies can be replicated in people living with type 2 diabetes or obesity

Some contraindications are absolute

Saki N, Vahedi S, Parvizi MM, Shafieei M, Hosseini SA, Ahramiyanpour N