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Exposure to inappropriate levels of endotoxin in a drug intended for injection raises safety concerns

their capillaries and veins (including mastoid emissary veins to the sigmoid sinus) can carry drug into the venous and arterial circulation around the inner ear

Some individuals report transient flushing, headache, or water retention during initial titration

Funding This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No