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and (v) coupling intracellular redox with inter-organ metabolism via the glutamyl cycle, GGT, and membrane transporters

Developmental expression and stress induction of glutathione S-transferase in the spruce budworm, Choristoneura fumiferana

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Furthermore, the network analysis showed a close relationship between various metabolic pathways, for example, between glutathione and alanine metabolism via glutamate metabolism, as well as between the metabolism of glycine and serine and alanine metabolism via glutamate metabolism and that of glucose-alanine cycle and alanine metabolism via transfer of acetyl groups into mitochondria

156 Besides, with the consumption of extracellular glutamine, GDH can also catalyze ammonia derived from glutaminolysis and -KG to support the synthesis of glutamate and downstream metabolites by reductive amination in a NADPH consumption manner to meet the cancer cells growth