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It dampens inflammatory cytokines like IL-6
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In cardiac cells, the physical proximity between mitochondria and the sarcoplasmic reticulum (SR, a specific type of ER in heart and skeletal muscle cells) allows the exchange of Ca 2+ in local microdomains, providing rapid Ca 2+ buffering
There's a bit of a twist here because coffee can acutely raise fasting blood glucose in some individuals and may slightly decrease insulin sensitivity in the short term, largely via acute sympathetic activation, but the overall long-term effect is protective
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