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The intrinsic pathway is activated by the oligomerization of the BCL2 family protein BAK and BAX, which contributing to the formation of oligomers from pores in the mitochondrial outer membranes, leading to the release of cytochrome c into the cytosol

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R PAPS is synthesized in two steps: ATP sulfurylase condenses ATP and inorganic sulfate to form adenosine-5'-phosphosulfate (APS), then APS kinase phosphorylates APS to form PAPS (at the cost of a second ATP)

& FitzGerald, D