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doi: 10.61622/rbgo/2024FPS04

Complete weight regain occurred in 23% of semaglutide, 21% of tirzepatide, and 27% of liraglutide users at 24 months

Usually, when people eat, it triggers the release of GLP-1

Its binding to the GIP receptor induces receptor internalization which, with continuous treatment, could lead to receptor downregulation and reduced GIP signaling (121)