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The first month on tirzepatide typically produces 3 to 5 pounds of weight loss, much of which is water weight and reduced food volume from appetite suppression

10.1016/j.phymed.2020.153218 213 SainiS.AroraS.MajidS.ShahryariV.ChenY.DengG.et al (2011)

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The likelihood ratio based on the objective function value was used to test different hypotheses regarding the structure of the variancecovariance matrix for inter-individual variability and residual variability models, and to assess the covariate effects on toxicokinetic parameters