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Transcriptmica (lnea de investigacin de Pickart) : Pickart et al
Additionally, capecitabine is well known to cause hand-foot syndrome (palmar-plantar erythrodysesthesia) , which, although classified dermatologically, shares mechanistic overlap with GI toxicity due to the drugs activation in high perfusion areas
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In the Th2-driven FITC-induced model, it is associated with the downregulation of IL-4 and IFN-, while in the Th17-driven oxazolone (OXZ) model, it suppresses phosphorylated STAT3 (p-STAT3) and IL-17A expression, ultimately contributing to the coordinated regulation of Th1, Th2, and Th17 immune axes (Dong et al., 2022)
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