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Jaggupilli A, Ly S, Borkar R, Nguyen K, Yuan B, Putluri N, Andreeff M , Battula VL
To examine the extent to which the phenotypes observed were specifically caused by lower GSH levels, we rescued GSH depletion in liver-specific Gclc KO mice with GSH mono ethyl ester (GSH-ee)
Protection against oxidative stress: Glutathione acts as a powerful antioxidant, neutralizing harmful free radicals and protecting cells from damage
However, when compared to wild type mice Ercc2+/- mice had fewer DNA strand breaks