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Importantly, microbiota changes observed during GLP-1 RA therapy may be influenced by confounding factors such as weight loss magnitude, dietary modifications, and concomitant treatments, particularly metformin

In order to comprehensively understand the effects of TMAO on NK cells, further research is necessary to elucidate these mechanisms and their impact on immune related diseases

SEMA was shown to be the most effective of its category in terms of meaningful weight reduction as it can penetrate certain areas in the central nervous system that are critical for hunger and appetite control and are not protected by the blood-brain barrier, regulating key appetite-modulating relay areas [70, 73]

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