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I always advise that when you start to get any of these symptoms in any combination, you go and ask your doctor to get your vitamin B12 levels checked

Whether a dull throb that accompanies stress or the sharper pain of a migraine attack, headaches are a universal affliction

This allows the vitamin to bypass the gastric system

Some medications can interfere with B12 absorption, including metformin (used for diabetes) and proton pump inhibitors (used for acid reflux)

The honest boundary is that even the coherent pairing is a mechanistic hypothesis with no human validation, so the most defensible research posture is to study the single compound at its documented dose first, and treat any combination as a further, clearly-labelled research question rather than a default