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Investigating the causal relationship between circulating inflammatory proteins and tinnitus: insights from a Mendelian randomization study

What they found (summary): NAD+ levels decline linearly with age in all tissues Sirtuins are glucose sensors , activated during caloric restriction and fasting The decline in NAD+ leads to pseudohypoxia in aging cells Supplementation with NAD+ precursors in animal models restores sirtuin activity Therapeutic perspectives: NMN, NR, sirtuin activators, CD38 inhibitors Why it matters: This is the reference article for the entire field

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Zucchini, C

Effect of GLY-HIS-LYS and its copper complex on TGF- secretion in normal human dermal fibroblasts