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More serious risks include pancreatitis (requiring immediate medical attention if severe abdominal pain occurs), gallbladder disease, and a boxed warning for medullary thyroid carcinoma risk (contraindicated in patients with personal/family history of MTC or Multiple Endocrine Neoplasia syndrome type 2)

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Semaglutide stimulates the pancreas to release insulin and lowers the hunger hormone ghrelin, thereby decreasing appetite and slowing stomach emptying