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Achieving a Steady State When you take a medication weekly, your body eventually reaches a steady state. This means the amount of medication you are absorbing is equal to the amount your body is clearing out

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This is the first Phase 3 GLP-1-class readout that specifically demonstrates symptomatic benefit in knee osteoarthritis beyond what would be expected from weight loss alone, and it opens the possibility, still to be confirmed in dedicated trials, that GLP-1 receptor signaling has direct anti-inflammatory or disease-modifying effects on joint tissue

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These changes were accompanied by increases in sperm morphological defects, testicular histology revealing the presence of germ cells, and severe degeneration of supporting and mesenchymal cells

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[Abstract]2023 Apr 11;28(8):3375

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