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Cardinal cutaneous manifestations of this disorder consist of sclerodermatous skin changes, ulcerations, atrophy, and pigmentation changes

right upper arm, left upper arm, abdomen, right upper thigh, left upper thigh)

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Consistent with these observations, treatment with pterostilbene, a natural inhibitor of SSBP1, effectively suppressed DNA-PK/p53 axis activation to alleviate high fructose-triggered ferroptosis in the glomerular podocytes