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Exogenous ipamorelin competes for the same GHS-R1a receptors, so dosing during a period of high endogenous ghrelin (immediately before a meal, or during prolonged fasting beyond 1618 hours when ghrelin peaks) can actually reduce net receptor occupancy through competitive inhibition

The NADP-GDH activity of Gdh1 and Gdh3 isoforms is unidirectional and specific for glutamate synthesis, while glutamate catabolism is performed via the action of the oxidizing form of GDH (NAD-GDH) that is also present in the GDH pathway

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