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These medications are another reminder that obesity is a complex chronic disease influenced by biology, genetics, medications, sleep, stress, food environments, and social factors

There are also more serious risks to consider, such as pancreatitis, gallbladder problems, kidney issues, thyroid tumors, and severe gastrointestinal conditions

This results in the translocation of Parkin to the mitochondria and initiation of mitochondrial degradation [322, 323], which helps to maintain neuronal homeostasis [324]

Immediate medical attention (call 999 or attend A&E) is warranted if patients experience symptoms suggesting serious complications, including: severe, persistent abdominal pain (particularly if radiating to the back, which may indicate pancreatitis)

In a large cohort study, nearly all cases of initial thyrotoxicosis evolved late hypothyroidism, with overt thyrotoxicosis occurring a median of 5 weeks after the first ICI dose and overt hypothyroidism developing a median of 14 weeks later (Muir et al