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Deleting METTL3 specifically in NK cells reduced their numbers and effector functions, impaired IL-15 responsiveness (via AKTmTOR/MAPK signaling), and accelerated tumor progression in mice ( in vivo ( 6 A pathways in NK cells tends to favor antitumor function

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The benefits of metabolic surgery need to be balanced against its potential adverse effects, which vary by procedure and include surgical complications, late metabolic or nutritional complications and impact on psychological health [5, 6, 127]