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Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

First, and perhaps most importantly, always remember that 5-Amino-1MQ is strictly for research purposes

Heap LC, Peters TJ, Wessely S

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It addresses why metabolism slows, not just how to force fat loss despite a struggling metabolism