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What users typically report: Sleep quality improvements become more consistent (less night-to-night variation) Night waking decreases particularly the 2-4am waking associated with cortisol surges Morning energy is noticeably improved Recovery from physical activity feels enhanced (growth hormone release during deep sleep is improved) Anxiety before sleep may be reduced, particularly in stress-driven insomnia By the end of week 1, the picture is usually clear: Whether someone is a DSIP responder

In in vivo and in vitro studies, melatonin was proven to increase the level of Nrf2 in cardiomyocytes exposed to oxidative stress

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